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Biotin
Biotin works in synergy with insulin in the body, and independently increases the activity of the enzyme glucokinase. Glucokinase is responsible for the first step of glucose utilisation, and is therefore an essential component of normal bodily functioning. Glucokinase occurs only in the liver, and in sufferers from diabetes its concentration may be extremely low. Supplements of biotin may have a significant effect on glucose levels for both type 1 and type 2 diabetics. Experts advise taking 16mg of biotin for several weeks and monitoring any fall in blood sugar levels.
Carnitine (L-Carnitine, Acetyl L-Carnitine)
Carnitine is required by the body in order to correctly use body fat in the production of energy. It is naturally occurring and derives from hydrophilic amino acids. Diabetics who try carnitine generally respond well, and high levels of fat in the bloodstream (cholesterol and triglycerides) may fall fast. Carnitine helps to break down fatty acids in the body and binds acyl residues. For these reasons, it may be useful to prevent diabetic ketoacidosis.
Chromium
Several principal double-blind studies have shown that supplemental chromium may raise glucose tolerance in patients with both type 1 and type 2 diabetes. Exercise also increases the concentration of tissue chromium. Chromium may have a role to play in pre-diabetics and women suffering from gestational diabetes.
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